蔬菜

白菜冻干粉降糖作用的初步药效学研究

Preliminary Pharmacodynamic Study on the Hypoglycemic Effect of Chinese Cabbage Freeze-Dried Powder

DOI：

英文关键词:Keywords: Chinese cabbage freeze-dried powder diabetes mellitus mouse blood sugar reduction

基金项目:江汉大学高层次人才科研启动项目（1010—08160001）。

作者	单位
刘钰莹1，王　宏1，段玉桦1，汤凌燕1，陈晓青1，黄　文2，凌智群1*	1.江汉大学医学院，湖北武汉 430056；2.华中农业大学食品科学技术学院，湖北武汉 430070

摘要点击次数: 381

全文下载次数: 0

中文摘要:

为探讨白菜冻干粉（Chinese Cabbage Freeze-Dried Powder，CCFDP）对高糖高脂饲料饲养小鼠餐后血糖的影响，对血糖筛选合格小鼠分别进行6组处理：正常对照组、高糖高脂饲料饲养造模对照组、造模＋同时口服灌胃CCFDP低剂量组、造模＋同时口服灌胃CCFDP高剂量组、造模＋造模15 d后再同时口服灌胃CCFDP低剂量组、造模＋造模15 d后再同时口服灌胃CCFDP高剂量组，45 d后检测小鼠餐后血糖值、血清中总胆固醇（T-CHO）、甘油三酯（TG）、高密脂蛋白（HDL-C）、低密脂蛋白（LDL-C）等指标。结果表明：与模型对照组比较，150 mg/（kg·d）CCFDP能有效降低高糖高脂饲料饲养小鼠的餐后血糖值以及血清TG和LDL-C。CCFDP能显著降低高糖高脂饲料饲养小鼠的餐后血糖，为糖尿病早期防治提供参考。

英文摘要:

Abstract: To investigate the hypoglycemic effect of Chinese Cabbage Freeze-Dried Powder (CCFDP) on diabetic mice, six groups of qualified mice after screening blood glucose were treated with control group, model rice fed with high-sugar and high-fat diet for 45 days, model rice + the oral administration of a high dose of CCFDP for 45 days at the same time, model rice + the oral administration of a low dose of CCFDP for 45 days at the same time, model rice + the oral administration of a high dose of CCFDP for 30 days after firstly feeding with high-sugar and high-fat diet for 15 days, model rice + the oral administration of a low dose of CCFDP for 30 days after firstly feeding with high-sugar and high-fat diet for 15 days, respectively. And then the serum bio-marker were tested, including the serum level of glucose, T-CHO, TG, HDL-C, LDL-C. The results showed that compared with that of model mice, the serum level of postprandial blood glucose and TG, LDL-C in the mice fed with 150 mg/(kg·d) CCFDP were significantly lower. The CCFDP could effectively prevent the production of diabetes in mice fed with high-sugar and high-fat diet, and had good potential application value for the prevention and treatme nt of diabetes.

查看全文查看/发表评论下载PDF阅读器

关闭